The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

Abstract excerpt

BACKGROUND: Brain tissue from patients with Alzheimer's disease has shown an increase of phosphorylation of Tyr-682, located on the conserved Y682ENPTY motif, and Thr-668 residues, both in the intracellular domain (AID) of amyloid beta precursor protein (APP), although the role of these two residues is not yet known. RESULTS: Here, we report that the phosphorylation status of Tyr-682, and in some cases Thr-668,...

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