Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting Protein<i>In Vivo</i>That Modulates Amyloidogenic Processing<i>In Vitro</i>

Abstract excerpt

Alzheimer's disease (AD) is an age-related neurodegenerative disease and the most common form of dementia. AD is pathologically characterized by the deposition of pathogenic Aβ peptides that are derived from larger integral membrane proteins, termed β-amyloid precursor proteins (APPs). In an attempt to understand the function of APP, in vitro studies have focused on the identification of interacting proteins. To...

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