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Article

Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain.

Journal of structural biology - 1 Jul 2014

Hoefgen Sandra, Coburger Ina, Roeser Dirk, Schaub Yvonne, Dahms Sven O, Than Manuel E

Abstract excerpt

The amyloid precursor protein (APP) and its cellular processing are believed to be centrally involved in the etiology of Alzheimer's disease (AD). In addition, many physiological functions have been described for APP, including a role in cell-cell- and cell-ECM-adhesion as well as in axonal outgrowth. We show here the molecular determinants of the oligomerization/dimerization of APP, which is central for its...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24859793
DOI: 10.1016/j.jsb.2014.05.006

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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