Article

Functional Separation of mRNA Domains Coordinates Pluripotent Cell Behavior

2022-03-17

Abstract excerpt

Differential expression of mRNA coding sequences (CDSs) and 3-prime untranslated regions (UTRs) is widespread, yet whether these domains contribute independently to cellular function remains unclear. Here, using Nanog as a model, we find that Nanog mRNA domain usage is spatially organized in mouse and human pluripotent cells and in the blastocyst, with cells enriched in 3-prime UTR transcripts marking colony borde...

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Literature Corpus work: 22256797-a55c-5607-bd6b-b21113dc13ae
DOI: 10.1101/2022.03.15.484504

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