Article
Nanog safeguards pluripotency and mediates germline development.
Nature - 20 Dec 2007
Chambers Ian, Silva Jose, Colby Douglas, Nichols Jennifer, Nijmeijer Bianca, Robertson Morag, Vrana Jan, Jones Ken, Grotewold Lars, Smith Austin
Abstract excerpt
Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and developing germ cells. Deletion of Nanog causes early embryonic lethality, whereas constitutive expression enables autonomous self-renewal of embryonic stem cells. Nanog is accordingly considered a core element of the pluripotent transcriptional network. However, here we report that Nanog fluctuates in mouse embryonic stem cells....
Topics
- Alleles
- Animals
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Chimera
- DNA-Binding Proteins
- Embryo, Mammalian
- Embryonic Stem Cells
- Gene Expression Regulation
- Germ Cells