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Article

Nanog safeguards pluripotency and mediates germline development.

Nature - 20 Dec 2007

Chambers Ian, Silva Jose, Colby Douglas, Nichols Jennifer, Nijmeijer Bianca, Robertson Morag, Vrana Jan, Jones Ken, Grotewold Lars, Smith Austin

Abstract excerpt

Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and developing germ cells. Deletion of Nanog causes early embryonic lethality, whereas constitutive expression enables autonomous self-renewal of embryonic stem cells. Nanog is accordingly considered a core element of the pluripotent transcriptional network. However, here we report that Nanog fluctuates in mouse embryonic stem cells....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18097409
DOI: 10.1038/nature06403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nanog safeguards pluripotency and mediates germline development.PMID 18097409Read ↗

Concise Review: Pursuing Self-Renewal and Pluripotency with the Stem Cell Factor NanogSemantic proximity Read ↗

Switching on pluripotency: a perspective on the biological requirement of Nanog.Semantic proximity Read ↗

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinctionSemantic proximity Read ↗

Control of ground-state pluripotency by allelic regulation of Nanog.Semantic proximity Read ↗

Activin/Nodal signalling maintains pluripotency by controlling Nanog expressionSemantic proximity Read ↗

Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.Semantic proximity Read ↗

ZMYM2 inhibits NANOG-mediated reprogrammingSemantic proximity Read ↗

A <i>Nanog</i> -dependent gene cluster initiates the specification of the pluripotent epiblastSemantic proximity Read ↗

NANOG initiates epiblast fate through the coordination of pluripotency genes expressionSemantic proximity Read ↗

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.Semantic proximity Read ↗

Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotencySemantic proximity Read ↗

Nanog-independent reprogramming to iPSCs with canonical factors.Semantic proximity Read ↗

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