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Article

NANOG initiates epiblast fate through the coordination of pluripotency genes expression

21 Jun 2022

Abstract excerpt

The epiblast is the source of all mammalian embryonic tissues and of pluripotent embryonic stem cells. It differentiates alongside the primitive endoderm in a "salt and pepper" pattern from inner cell mass (ICM) progenitors during the preimplantation stages through the activity of NANOG, GATA6 and the FGF pathway. When and how epiblast lineage specification is initiated is still unclear. Here, we show that the...

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PMID: 35729116
DOI: 10.1038/s41467-022-30858-8

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NANOG initiates epiblast fate through the coordination of pluripotency genes expressionPMID 35729116Read ↗

A <i>Nanog</i> -dependent gene cluster initiates the specification of the pluripotent epiblastSemantic proximity Read ↗

Control of ground-state pluripotency by allelic regulation of Nanog.Semantic proximity Read ↗

Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.Semantic proximity Read ↗

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.Semantic proximity Read ↗

Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signalingSemantic proximity Read ↗

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.Semantic proximity Read ↗

Activin/Nodal signalling maintains pluripotency by controlling Nanog expressionSemantic proximity Read ↗

Switching on pluripotency: a perspective on the biological requirement of Nanog.Semantic proximity Read ↗

NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo.Semantic proximity Read ↗

FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse.Semantic proximity Read ↗

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinctionSemantic proximity Read ↗

Human hypoblast formation is not dependent on FGF signallingSemantic proximity Read ↗

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