Article

Unwinding of RNA G-quadruplexes induces mouse and human totipotency

2026-02-15

Abstract excerpt

Totipotent stem cells (TotiSCs) have significant application prospects in regenerative medicine and assisted reproductive technologies. The mRNAs of totipotency-related genes are rich in G-quadruplex (G4) structures, while the G4 density of pluripotency-related genes mRNAs is relatively low, suggesting a potential functional link between RNA G4s and the totipotent state. Nevertheless, how G4s are involved in the e...

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Literature Corpus work: 66dc4da8-c904-562d-bd6a-d2d8ef7af22f
DOI: 10.64898/2026.02.13.703305

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