Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.

doi:10.1074/jbc.M111.290189

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Article

Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.

The Journal of biological chemistry - 9 Dec 2011

Das Satyabrata, Jena Snehalata, Levasseur Dana N

Abstract excerpt

Embryonic stem (ES) cells are distinguished by their ability to undergo unlimited self-renewal although retaining pluripotency, the capacity to specify cells of all germ layers. Alternative splicing contributes to these biological processes by vastly increasing the protein coding repertoire, enabling genes to code for novel variants that may confer different biological functions. The homeodomain transcription...

Topics

Alternative Splicing
Animals
Cell Differentiation
Cell Line
DNA-Directed RNA Polymerases
Embryonic Stem Cells
Genetic Variation
Homeodomain Proteins
Humans
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nanog Homeobox Protein

Pluripotent Stem Cells

Protein Structure, Tertiary

RNA

Stem Cells

Transcription, Genetic

Source

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Identifiers

PMID: 21969378
DOI: 10.1074/jbc.M111.290189
PMCID: PMC3234911

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