Article
Transcriptional regulation of nanog by OCT4 and SOX2.
The Journal of biological chemistry - 1 Jul 2005
Rodda David J, Chew Joon-Lin, Lim Leng-Hiong, Loh Yuin-Han, Wang Bei, Ng Huck-Hui, Robson Paul
Abstract excerpt
Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog. Within the Nanog proximal promoter, we identify a composite sox-oct cis-regulatory...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Nucleus
- Cell Separation
- Chromatin Immunoprecipitation
- DNA-Binding Proteins
- Databases, Genetic
- Dimerization
- Embryo, Mammalian
- Flow Cytometry
- Gene Expression Regulation
- Genes, Reporter
- Green Fluorescent Proteins