Article

High-Specificity Detection of Chromosomal Mosaicism Reveals Cell-Type-Specific Genomic Alteration Patterns in Aging Tissues

2026-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Mosaic chromosomal alterations (mCAs) increase with age and are associated with multiple diseases, yet the cell types and states that harbor these alterations remain largely unknown. Because mCAs arise in individual cells prior to clonal expansion, they are typically rare and obscured in bulk data. We develop CHASM, a method for detecting chromosomal copy number alterations (CNA) from single-cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 212557c2-93d8-5dad-b8d3-236bf06d42dd
DOI: 10.64898/2026.08.02.741928

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-Specificity Detection of Chromosomal Mosaicism Reveals Cell-Type-Specific Genomic Alteration Patterns in Aging TissuesDOI 10.64898/2026.08.02.741928Read

Somatic copy-number alteration signatures reveal sex-divergent aging trajectories accelerated in cancerSemantic proximity Read

Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease.Semantic proximity Read

Hematopoietic mosaic chromosomal alterations are pleiotropic drivers of inflammaging, multimorbidity, and mortalitySemantic proximity Read

Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer.Semantic proximity Read

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidneySemantic proximity Read

TeaCNV: decoding tumor somatic absolute copy number and clonal architecture from single cell chromatin accessibility dataSemantic proximity Read

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals.Semantic proximity Read

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.Semantic proximity Read

Tracking single cell evolution via clock-like chromatin accessibilitySemantic proximity Read

Origins of <i>de novo</i> chromosome rearrangements unveiled by coupled imaging and genomicsSemantic proximity Read

Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissuesSemantic proximity Read

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Semantic proximity Read