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Article

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals.

Nature genetics - 1 Nov 2023

Gao Teng, Kastriti Maria Eleni, Ljungström Viktor, Heinzel Andreas, Tischler Arthur S, Oberbauer Rainer, Loh Po-Ru, Adameyko Igor, Park Peter J, Kharchenko Peter V

Abstract excerpt

Genetic mutations accumulate in an organism's body throughout its lifetime. While somatic single-nucleotide variants have been well characterized in the human body, the patterns and consequences of large chromosomal alterations in normal tissues remain largely unknown. Here, we present a pan-tissue survey of mosaic chromosomal alterations (mCAs) in 948 healthy individuals from the Genotype-Tissue Expression...

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Identifiers

PMID: 37904053
DOI: 10.1038/s41588-023-01537-1
PMCID: PMC10838621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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