Article

TeaCNV: decoding tumor somatic absolute copy number and clonal architecture from single cell chromatin accessibility data

2025-05-21

Abstract excerpt

<title>Abstract</title> <p>Accurate inference of absolute copy numbers beyond simple gains and losses from single-cell chromatin accessibility (scATAC-seq) data remains challenging, thereby obscuring the distinction between genetic and epigenetically driven oncogenic dependencies. Here, we present TeaCNV, a computational framework that reconstructs clonal absolute copy number profiles and tumor clonal architectur...

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Literature Corpus work: b6cdd2e1-047d-58fc-b2bb-b611c93ba4f8
DOI: 10.21203/rs.3.rs-6609843/v1

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