Origins of <i>de novo</i> chromosome rearrangements unveiled by coupled imaging and genomics

Abstract excerpt

Chromosomal instability results in widespread structural and numerical chromosomal abnormalities (CAs) during cancer evolution 1–3 . While CAs have been linked to mitotic errors resulting in the emergence of nuclear atypias 4–7 , the underlying processes and basal rates of spontaneous CA formation in human cells remain under-explored. Here we introduce machine learning-assisted genomics-and-imaging convergence (...

Topics

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• Chromosomal Instability
• Chromosome Aberrations
• DNA Breaks, Double-Stranded
• Genomics
• Machine Learning
• Mutation Rate
• Single-Cell Analysis
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

fe76797f-5e2a-57ae-b9b6-803b6c4b2590

DOI

10.1101/2024.08.15.607890