Article

Somatic copy-number alteration signatures reveal sex-divergent aging trajectories accelerated in cancer

2026-05-23

Abstract excerpt

Somatic copy-number alterations (CNAs) accumulate with age and contribute to age-related pathologies, but their systematic characterization at single-cell resolution has been limited by the throughput-resolution trade-off in single-cell whole-genome sequencing. Here, we developed ultra-CNA, a high-resolution single-cell analysis pipeline that extends CNA detection to 10-kb bin resolution and jointly profiles copy-...

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Literature Corpus work: ccc88b23-0aeb-5986-8d71-73868054839d
DOI: 10.64898/2026.05.20.726597

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