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Article

Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease.

Genome biology - 29 Jan 2024

Wilson Parker C, Verma Amit, Yoshimura Yasuhiro, Muto Yoshiharu, Li Haikuo, Malvin Nicole P, Dixon Eryn E, Humphreys Benjamin D

Abstract excerpt

BACKGROUND: Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY is present in the kidney and increases with age and chronic kidney disease. RESULTS: The likelihood of a cell having LOY varies depending on its location in the nephron. Cortical epithelial cell types have a greater proportion of LOY than medullary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Renal Insufficiency, Chronic

Source

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Identifiers

PMID: 38287344
DOI: 10.1186/s13059-024-03173-2
PMCID: PMC10823641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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