Article

Hematopoietic mosaic chromosomal alterations are pleiotropic drivers of inflammaging, multimorbidity, and mortality

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Mosaic chromosomal alterations (mCAs) are a prevalent but poorly understood form of clonal hematopoiesis (CH). Whether mCAs contribute to disease independently of CHIP, and whether their large-scale genomic effects can be resolved to actionable targets, remain unknown. In 452,594 UK Biobank participants, we show that mCAs confer multimorbidity and mortality risk independent of CHIP. Notably, mCA...

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Literature Corpus work: 604408a7-c95f-5481-be81-0f8a52d4d34a
DOI: 10.64898/2026.06.24.26356446

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