Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer.

Nature biotechnology - 1 Jan 2020

Jakubek Y A, Chang K, Sivakumar S, Yu Y, Giordano M R, Fowler J, Huff C D, Kadara H, Vilar E, Scheet P

Abstract excerpt

Mosaicism, the presence of subpopulations of cells bearing somatic mutations, is associated with disease and aging and has been detected in diverse tissues, including apparently normal cells adjacent to tumors. To analyze mosaicism on a large scale, we surveyed haplotype-specific somatic copy number alterations (sCNAs) in 1,708 normal-appearing adjacent-to-tumor (NAT) tissue samples from 27 cancer sites and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clone Cells

Share to DNA Copy Number Variations

Share to Genome, Human

Share to Mosaicism

Share to Neoplasms

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 31685958
DOI: 10.1038/s41587-019-0297-6
PMCID: PMC8082517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer.PMID 31685958Read ↗

A pan-tissue survey of mosaic chromosomal alterations in 948 individuals.Semantic proximity Read ↗

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Semantic proximity Read ↗

Pan-cancer patterns of somatic copy number alteration.Semantic proximity Read ↗

Aging and the rise of somatic cancer-associated mutations in normal tissues.Semantic proximity Read ↗

High-Specificity Detection of Chromosomal Mosaicism Reveals Cell-Type-Specific Genomic Alteration Patterns in Aging TissuesSemantic proximity Read ↗

A comprehensive view of somatic mosaicism by single-cell DNA analysisSemantic proximity Read ↗

Landscape of human protein-coding somatic mutations across tissues and individualsSemantic proximity Read ↗

Luminal breast epithelial cells from wildtype and <i>BRCA</i> mutation carriers harbor copy number alterations commonly associated with breast cancerSemantic proximity Read ↗

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs.Semantic proximity Read ↗

The Somatic Mosaicism across Human Tissues Network.Semantic proximity Read ↗

Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations.Semantic proximity Read ↗

Cells with cancer‐associated mutations overtake our tissues as we ageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.