Article

Tracking single cell evolution via clock-like chromatin accessibility

2022-05-13

Abstract excerpt

Single cell chromatin accessibility sequencing (scATAC) reconstructs developmental trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is challenging. Here, we show a simple, accurate and phenotypic-neutral measure of cell developmental hierarchy -- the fraction of accessible clock-like loci. As cells undergo mitosis, the heterogeneity of chromatin accessibility on clock-like...

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Identifiers and source

Literature Corpus work: b11e5f21-dfa0-5ac3-997e-8f75e821c5b3
DOI: 10.1101/2022.05.12.491736

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