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Article

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.

Nature reviews. Genetics - 1 Nov 2025

Shao Diane D, Kriz Andrea J, Snellings Daniel A, Zhou Zinan, Zhao Yifan, Enyenihi Liz, Walsh Christopher

Abstract excerpt

DNA sequencing from bulk or clonal human tissues has shown that genetic mosaicism is common and contributes to both cancer and non-cancerous disorders. However, single-cell resolution is required to understand the full genetic heterogeneity that exists within a tissue and the mechanisms that lead to somatic mosaicism. Single-cell DNA-sequencing technologies have traditionally trailed behind those of single-cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40281095
DOI: 10.1038/s41576-025-00832-3

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