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SECEDO: SNV-based subclone detection using ultra-low coverage single-cell DNA sequencing.

Bioinformatics (Oxford, England) - 15 Sept 2022

Rozhoňová Hana, Danciu Daniel, Stark Stefan, Rätsch Gunnar, Kahles André, Lehmann Kjong-Van

Abstract excerpt

MOTIVATION: Several recently developed single-cell DNA sequencing technologies enable whole-genome sequencing of thousands of cells. However, the ultra-low coverage of the sequenced data (<0.05× per cell) mostly limits their usage to the identification of copy number alterations in multi-megabase segments. Many tumors are not copy number-driven, and thus single-nucleotide variant (SNV)-based subclone detection...

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Identifiers

PMID: 35900151
DOI: 10.1093/bioinformatics/btac510
PMCID: PMC9477524

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