Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo.

Abstract excerpt

Accurate single cell mutational profiles can reveal genomic cell-to-cell heterogeneity. However, sequencing libraries suitable for genotyping require whole genome amplification, which introduces allelic bias and copy errors. The resulting data violates assumptions of variant callers developed for bulk sequencing. Thus, only dedicated models accounting for amplification bias and errors can provide accurate calls....

Topics

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• Genetic Techniques
• Genomics
• High-Throughput Nucleotide Sequencing
• Mutation
• Polymorphism, Single Nucleotide