Article

Somatic variant detection in normal tissues from single-cell sequencing data

2026-06-14

Abstract excerpt

A crucial advantage of single-cell sequencing (SCS) is its ability to identify somatic variants in individual cells, enabling phylogenetic analysis of cellular populations within bulk tissues. While identifying somatic variants in tumor tissues via SCS has become a common practice, doing so in normal tissues remains challenging due to the rarity of somatic variants in normal cells. To evaluate the feasibility of s...

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Literature Corpus work: 9878406e-c203-5134-a3c8-a56a7b4fbd03
DOI: 10.64898/2026.06.10.731451

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