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Article

Integrating SNVs and CNAs on a phylogenetic tree from single-cell DNA sequencing data.

Genome research - 1 Dec 2023

Zhang Liting, Bass Hank W, Irianto Jerome, Mallory Xian

Abstract excerpt

Single-cell DNA sequencing enables the construction of evolutionary trees that can reveal how tumors gain mutations and grow. Different whole-genome amplification procedures render genomic materials of different characteristics, often suitable for the detection of either single-nucleotide variation or copy number aberration, but not ideally for both. Consequently, this hinders the inference of a comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37993137
DOI: 10.1101/gr.277249.122
PMCID: PMC10760445

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