Article

An image segmentation pipeline optimized for human microglia uncovers sources of morphological diversity in Alzheimer’s disease

2024-02-07

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and the accumulation of beta-amyloid plaques and neurofibrillary tangles. Microglia, the resident immune cells in the brain, play a crucial role in AD pathology, particularly in relation to amyloid plaques. However, the exact role of plaque-associated microglia and their morphological changes in AD progression remains under...

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Literature Corpus work: 04f9f134-f44a-54f4-836c-27290377ea7e
DOI: 10.1101/2024.02.01.577128

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