Article

Spatiotemporal Characterization of Amyloidosis-Associated Microglial States Reveals Sex Difference in Early Plaque Formation

2026-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Twice as many women develop Alzheimer’s disease (AD) compared to men. Several key aspects, such as genetic risk factors, hormonal vulnerability, social responsibilities, and differences in longevity, contribute to the strong female bias in AD. To assess whether sex differences can be detected during the onset of AD, we examined the amyloid-β (Aβ) plaque burden––one of the hallmarks of AD––and mi...

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Literature Corpus work: e00d1b90-ef15-5b7e-98f2-7a448f2e24dd
DOI: 10.64898/2026.04.05.716600

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