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Article

Activated microglial phenotypes in the hippocampal CA2 subfield are implicated in Lewy body disease progression.

Acta neuropathologica - 8 Aug 2026

Luna Esteban, Cousins Katheryn A Q, Emrani Sheina, Xie Sharon X, Trotman Winifred, Capp Noah, Sabatini Philip, Pouladvand Parham, Suh EunRan, Van Deerlin Vivianna M, Weintraub Daniel, Chen-Plotkin Alice S, Lee Edward B, Irwin David J

Abstract excerpt

Histopathologic staging models of neuronal α-synuclein pathology (n-asyn) in Lewy body disease (LBD) seldom evaluate brain regions with direct synaptic connectivity to model the role of microglial processes. We address this gap by testing the hypothesis that, within the well-defined synaptic connectivity of the intrahippocampal circuit, n-asyn is associated with activated microglial phenotypes. We selected a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42570991
DOI: 10.1007/s00401-026-03065-8
PMCID: PMC13452847

Genes

CA2
CD68

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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