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Article

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes.

Nature neuroscience - 1 Oct 2022

Colombo Gloria, Cubero Ryan John A, Kanari Lida, Venturino Alessandro, Schulz Rouven, Scolamiero Martina, Agerberg Jens, Mathys Hansruedi, Tsai Li-Huei, Chachólski Wojciech, Hess Kathryn, Siegert Sandra

Abstract excerpt

Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenotypes. Here we develop MorphOMICs, a topological data analysis approach, which enables semiautomatic mapping of microglial morphology into an atlas of...

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PMID: 36180790
DOI: 10.1038/s41593-022-01167-6
PMCID: PMC9534764

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