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Article

Association between APOE genotype and microglial cell morphology.

Journal of neuropathology and experimental neurology - 20 Jun 2023

Kloske Courtney M, Gearon Mary D, Weekman Erica M, Rogers Colin, Patel Ela, Bachstetter Adam, Nelson Peter T, Wilcock Donna M

Abstract excerpt

APOE is the largest genetic risk factor for late-onset Alzheimer disease (AD) with E4 conferring an increased risk for AD compared to E3. The ApoE protein can impact diverse pathways in the brain including neuroinflammation but the precise impact of ApoE isoforms on inflammation remains unknown. As microglia are a primary source of neuroinflammation, this study determined whether ApoE isoforms have an impact on...

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Identifiers

PMID: 37087107
DOI: 10.1093/jnen/nlad031
PMCID: PMC10280358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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