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Article

Plaque vicinity as a hotspot of microglial turnover in a mouse model of Alzheimer's disease

19 Aug 2023

Abstract excerpt

Microglia, the major immune cells of the brain, are functionally heterogeneous but in vivo functional properties of these cells are rarely studied at single-cell resolution. By using microRNA-9 regulated viral vectors for multicolor labeling and longitudinal in vivo monitoring of individual microglia, we followed their fate in the cortex of healthy adult mice and at the onset of amyloidosis in a mouse model of...

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PMID: 37596829
DOI: 10.1002/glia.24458

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