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Article

Beyond Activation: Characterizing Microglial Functional Phenotypes.

Cells - 28 Aug 2021

Lier Julia, Streit Wolfgang J, Bechmann Ingo

Abstract excerpt

Classically, the following three morphological states of microglia have been defined: ramified, amoeboid and phagocytic. While ramified cells were long regarded as "resting", amoeboid and phagocytic microglia were viewed as "activated". In aged human brains, a fourth, morphologically novel state has been described, i.e., dystrophic microglia, which are thought to be senescent cells. Since microglia are not...

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Identifiers

PMID: 34571885
DOI: 10.3390/cells10092236
PMCID: PMC8464670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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