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APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice

21 May 2019

Abstract excerpt

Microglia affect Alzheimer's disease (AD) pathogenesis in opposing manners, by protecting against amyloid accumulation in early phases of the disease and promoting neuropathology in advanced stages. Recent research has identified specific microglial interactions with amyloid plaques that exert important protective functions including attenuation of early pathology. It is unknown how these protective microglial...

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PMID: 31113487
DOI: 10.1186/s40478-019-0729-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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