Article

In situ structures from relaxed cardiac myofibrils reveal the organization of the muscle thick filament

2023-04-11

Abstract excerpt

The thick filament is a key component of sarcomeres, the basic force-generating and load-bearing unit of striated muscle 1 . Mutations in thick filament proteins are associated with familial hypertrophic cardiomyopathy and other heart and muscle diseases 2, 3 . Despite this central importance for sarcomere force generation, it remains unclear how thick filaments are structurally organized and how its components...

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Literature Corpus work: 20d14c87-266c-5801-bb48-443c1084867e
DOI: 10.1101/2023.04.11.536387

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