Article

Cryo-ET reveals nanoscale thick filament disorganization in MYH7 P710R hypertrophic cardiomyopathy cardiomyocytes

2026-02-18

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common monogenic inherited heart disease and is a major cause of sudden death in individuals under 35 years of age. HCM is associated with progressive tissue-level disarray and subcellular disorganization in individual cardiomyocytes. Mutations in β-cardiac myosin (MYH7), the second most common genetic cause of HCM, commonly result in changes in sarcomeric force produc...

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Literature Corpus work: 532cad5b-6f7e-5b9b-bd8d-539a9ad8ba09
DOI: 10.64898/2026.02.18.706593

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