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Article

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.

Science (New York, N.Y.) - 18 Feb 2022

Wang Zhexin, Grange Michael, Pospich Sabrina, Wagner Thorsten, Kho Ay Lin, Gautel Mathias, Raunser Stefan

Abstract excerpt

In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the underlying mechanism remains nebulous. In this work, we used cryo-electron tomography and subtomogram averaging to reveal structures of native nebulin bound to thin filaments within intact sarcomeres. This in situ reconstruction provided high-resolution details of the interaction between nebulin and actin, demonstrating the...

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Identifiers

PMID: 35175800
DOI: 10.1126/science.abn1934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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