Article

Sub-sarcomeric regulation of thin and thick filaments in skeletal muscle myofibrils

2025-11-21

Abstract excerpt

Muscle contraction relies on the coordinated activation of myosin motors from a folded-OFF state on the thick filament surface and their actin tracks on the thin filaments in response to calcium. Thick filaments contain distinct regulatory zones defined by the presence of myosin-binding protein C (MyBP-C) and titin super-repeats, but the control of myosin OFF/ON states within these zones has not been directly reso...

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Identifiers and source

Literature Corpus work: db15619c-7211-5552-8317-20728f06a6f3
DOI: 10.1101/2025.11.21.689690

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