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Article

Thick Filament Protein Network, Functions, and Disease Association.

Comprehensive Physiology - 13 Mar 2018

Wang Li, Geist Janelle, Grogan Alyssa, Hu Li-Yen R, Kontrogianni-Konstantopoulos Aikaterini

Abstract excerpt

Sarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along with accessory proteins. Thick filaments occupy the center of sarcomeres where they partially overlap with thin filaments. The sliding of thick filaments past thin filaments is a highly regulated process that occurs in an ATP-dependent manner driving muscle contraction. In addition to myosin that makes up the backbone of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29687901
DOI: 10.1002/cphy.c170023
PMCID: PMC6404781

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