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A robust and inducible precise genome editing via an all-in-one prime editor in human pluripotent stem cells

2024-01-20

Abstract excerpt

Prime editing (PE) allows for precise genome editing in human pluripotent stem cells (hPSCs), such as introducing single nucleotide modifications, small deletions, or insertions at a specific genomic locus, a strategy that shows great promise for creating “Disease in a dish” models. To improve the effectiveness of prime editing in hPSCs, we systematically compared and combined the “inhibition of mismatch repair pa...

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Literature Corpus work
209f1d5b-9c09-584d-848a-bd70b4663ad4
DOI
10.1101/2024.01.18.576233
Open publication

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A robust and inducible precise genome editing via an all-in-one prime editor in human pluripotent stem cellsDOI 10.1101/2024.01.18.576233
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