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Prime editing: A gene precision editing tool from inception to present.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 15 Nov 2024

Liu Zhihao, Guo Dong, Wang Dawei, Zhou Jinglin, Chen Qi, Lai Junzhong

Abstract excerpt

Genetic mutations significantly contribute to the onset of diseases, with over half of the cases caused by single-nucleotide mutations. Advances in gene editing technologies have enabled precise editing and correction of mutated genes, offering effective treatment methods for genetic disorders. CRISPR/Cas9, despite its power, poses risks of inducing gene mutations due to DNA double-strand breaks (DSB). The advent...

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PMID: 39530600
DOI: 10.1096/fj.202401692R

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