Article

Optimized nickase- and nuclease-based prime editing in human and mouse cells

2021-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Precise genomic modification using prime editing (PE) holds enormous potential for research and clinical applications. Currently, the delivery of PE components to mammalian cell lines requires multiple plasmid vectors. To overcome this limitation, we generated all-in-one prime editing (PEA1) constructs that carry all the components required for PE, along with a selection marker. We tested these...

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Literature Corpus work: 32c224a0-d480-52e4-9028-d939d788543b
DOI: 10.1101/2021.07.01.450810

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