Article

Persistent mTORC1 activation underlies sex dimorphic progression of MASLD in mice with hepatocyte prohibitin-1 deficiency

2025-09-25

Abstract excerpt

<title>Abstract</title> <p> Prohibitins (PHB1,2) are highly conserved lipid-raft associated proteins that physically interact to form a multimeric ring supercomplex in mitochondrial and plasma membranes where they are intimately involved in regulating cellular metabolism. Prior studies in disparate cell models have implicated PHB1 as a mediator of insulin signaling and its downstream effector, the mechanistic ta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 208816ee-6cdb-53ce-9de3-db04f2237d28
DOI: 10.21203/rs.3.rs-7481614/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Persistent mTORC1 activation underlies sex dimorphic progression of MASLD in mice with hepatocyte prohibitin-1 deficiencyDOI 10.21203/rs.3.rs-7481614/v1Read

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in MiceSemantic proximity Read

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)Semantic proximity Read

<i>Ybx1</i> guides C/EBPα and cBAF chromatin-remodeling complex to promote adipogenic gene expression in steatotic hepatocytesSemantic proximity Read

Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner.Semantic proximity Read

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in miceSemantic proximity Read

Adipocyte JAK2 mediates aging-associated metabolic liver disease and progression to hepatocellular carcinomaSemantic proximity Read

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progressionSemantic proximity Read

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial functionSemantic proximity Read

Rap1 Activation Protects Against Fatty Liver and Non-Alcoholic Steatohepatitis DevelopmentSemantic proximity Read

Hepatic HKDC1 Deletion Alleviates Western Diet-Induced MASH in MiceSemantic proximity Read

MTARC1 Regulates Lipid Droplet Degradation via Phospholipid Remodeling in Metabolic Fatty Liver DiseaseSemantic proximity Read

Hepatocyte Rap1a Contributes To Obesity- and Statin-Associated HyperglycemiaSemantic proximity Read