Article

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progression

2025-11-07

Abstract excerpt

<h4>Objective</h4> Primary liver cancer is a leading cause of cancer-related mortality and harbors recurrent mutations in chromatin regulators such as BRCA1-associated protein 1 (BAP1), yet their functional impact remains unclear. We investigated how BAP1 deficiency affects liver homeostasis and tumorigenesis to clarify its functional role. <h4>Design</h4> We employed inducible, liver-specific BAP1 knockdown in...

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Literature Corpus work: 5b477f5f-05a0-5791-9244-d73dc4554be0
DOI: 10.1101/2025.11.06.686752

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