Article

Rap1 Activation Protects Against Fatty Liver and Non-Alcoholic Steatohepatitis Development

2023-10-24

Abstract excerpt

We previously demonstrated that hepatic activation of a small G protein of the Ras family, Rap1a, is suppressed in obesity, which results in increased hepatic glucose production and glucose intolerance in obese mice. Here, we show that Rap1a inhibition in obese mice liver also results in fatty liver formation, which is characteristic of the diabetic liver. Specifically, we report that Rap1a activity is decreased i...

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Literature Corpus work: dfbc38b3-4b3f-5bde-b4fe-ee1f497ad612
DOI: 10.1101/2023.10.24.563728

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