Article

Hepatocyte Rap1a Contributes To Obesity- and Statin-Associated Hyperglycemia

2022-06-26

Abstract excerpt

<h4>SUMMARY</h4> Excessive hepatic glucose production contributes to the development of hyperglycemia and is a key feature of type 2 diabetes. Here, we report that activation of hepatic Rap1a suppresses gluconeogenic gene expression and glucose production, whereas Rap1a silencing stimulates them. Rap1a activation is suppressed in obese mouse liver and restoring its activity lowers blood glucose and improves gluco...

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Literature Corpus work: da64a273-c3cd-5d39-8de3-c91021bc9cb3
DOI: 10.1101/2022.06.25.497009

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