Article

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)

2025-08-10

Abstract excerpt

<h4>ABSTRACT</h4> The circadian clock synchronizes physiological processes with the 24-hour light-dark cycle. Clock disruption contributes to metabolic disorders, including metabolic dysfunction-associated steatohepatitis (MASH). Here, we investigated the role of the hepatocyte clock in MASH using hepatocyte-specific Bmal1 deletion (Hep-Bmal1KO) mice. Hep-Bmal1KO mice showed faster MASH progression with increase...

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Literature Corpus work: ebda2551-5ccd-5e5c-bce2-48c4b775ae13
DOI: 10.1101/2025.08.07.669039

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