Article

Adipocyte JAK2 mediates aging-associated metabolic liver disease and progression to hepatocellular carcinoma

2019-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are liver manifestations of the metabolic syndrome and can progress to hepatocellular carcinoma (HCC). Loss of Growth Hormone (GH) signaling is reported to predispose to NAFLD and NASH through direct actions on the liver. Here, we report that aged mice lacking hepatocyte Jak2 (JAK2L), an obligate transducer of Growth Hormone (...

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Literature Corpus work: 7737470e-3d74-505b-ab2b-0fdf2bac35f7
DOI: 10.1101/681809

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