Article

Evidence of positive and negative selection associated with DNA methylation

2021-11-25

Abstract excerpt

Signatures of negative selection are pervasive amongst complex traits and diseases. However, it is unclear whether such signatures exist for DNA methylation (DNAm) that has been proposed to have a functional role in disease. We estimate polygenicity, SNP-based heritability and model the joint distribution of effect size and minor allele frequency (MAF) to estimate a selection coefficient ( S ) for 2000 heritable...

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Literature Corpus work: 207746bb-3cb5-5b97-b2e4-f3bfae11986b
DOI: 10.1101/2021.11.25.469994

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