Article
An evolutionary compass for detecting signals of polygenic selection and mutational bias
2017-08-08
Abstract excerpt
Selection and mutation shape genetic variation underlying human traits, but the specific evolutionary mechanisms driving complex trait variation are largely unknown. We developed a statistical method that uses polarized GWAS summary statistics from a single population to detect signals of mutational bias and selection. We found evidence for non-neutral signals on variation underlying several traits (BMI, schizophr...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 10e09eb1-1ad1-5435-b8c6-2e83499bc93f
- DOI
- 10.1101/173815