Article

Identification of Dynamic Genetic Influences on DNA Methylation from Birth to Adulthood

2026-03-10

Abstract excerpt

Whether and how genetic regulation of DNA methylation (DNAm) change across the lifespan remains unclear. Here, we map age-dependent methylation quantitative trait loci (longitudinal mQTLs) using linear mixed models applied to repeated blood DNAm measures from birth, childhood, adolescence and adulthood in the Avon Longitudinal Study of Parents and Children. We identify 2,210 longitudinal mQTLs (2,393 SNP-CpG pairs...

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Literature Corpus work: 712089a8-6c0a-533a-a960-181dbe488cc2
DOI: 10.64898/2026.03.09.710470

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