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Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data.

Genetics - 1 Dec 2017

Robins Chloe, McRae Allan F, Powell Joseph E, Wiener Howard W, Aslibekyan Stella, Kennedy Elizabeth M, Absher Devin M, Arnett Donna K, Montgomery Grant W, Visscher Peter M, Cutler David J, Conneely Karen N

Abstract excerpt

The evolutionary theories of mutation accumulation (MA) and disposable soma (DS) provide possible explanations for the existence of human aging. To better understand the relative importance of these theories, we devised a test to identify MA- and DS-consistent sites across the genome using familial DNA methylation data. Two key characteristics of DNA methylation allowed us to do so. First, DNA methylation...

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Identifiers

PMID: 28855307
DOI: 10.1534/genetics.117.300217
PMCID: PMC5714465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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