Article

Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits

2017-09-13

Abstract excerpt

Understanding the role of rare variants is important in elucidating the genetic basis of human diseases and complex traits. It is widely believed that negative selection can cause rare variants to have larger per-allele effect sizes than common variants. Here, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP effect sizes. We use a model in which per-allele effect sizes have varian...

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Literature Corpus work: 954e6e0b-9629-51d7-9f97-7c39d2774731
DOI: 10.1101/188086

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